Sportsbooks Online x Bet365 Thursday Night Football Odds Boost

The SportsbooksOnline.com TNF Boost is back for Week 5 on Bet365! We did the legwork to research and build a three-leg parlay for Thursday night's matchup between the 49ers and Rams in LA, and with boosted odds from Bet365, we think it will help NFL bettors win big on Thursday night.

Each of these NFC West foes enters Week 5 with a 3-1 record, but there's one major factor influencing betting lines in this game: 49ers QB Brock Purdy, who missed Weeks 2 and 3 with a form of turf toe before returning in Week 4, is once again questionable to play in Week 5. Given Purdy's up-in-the-air status, here are the legs we like to hit on Thursday night:

• Rams Moneyline
• Kyren Williams Anytime TD
• Christian McCaffrey 60+ Rush Yards

This SGP has been boosted from +325 to +400 for Bet365 users in all legal US states, so a $10 bet would return a profit of $40 if all four legs hit.

With Purdy potentially sidelined, the Rams have moved to 6.5-point favorites at home on most football sportsbooks. It's otherwise a fairly evenly-matched game between two opponents who know each other very well. But with the Niners either starting Mac Jones or a hobbling Purdy under center, we think the Rams are a safe pick to earn the W in this contest.

And we think RB Kyren Williams is a big reason why the Rams will win this game. The Rams have boasted a top-five passing offense so far this year, but Robert Saleh's defense has allowed the sixth-fewest yards per game through the air. With the Rams expected to set the pace for this game, we think they'll feed Kyren Williams the ball plenty. And for a back who scored 14 touchdowns on the ground a year ago and has just one so far this year, it looks like Kyren Williams' week to get back in rhythm in the red zone.

Finally, with precarity at the quarterback position, San Francisco will have to rely on other playmakers to generate offense. That means RB Christian McCaffrey will have a leading role on Thursday night, getting plenty of touches that should land him at 60 or more rushing yards on the evening. McCaffrey averaged more than 60 yards per game for eight straight seasons before injuries derailed his 2024 season, so the Niners' bellcow has a great chance to surpass that number come Thursday.

This will be available to users in all Bet365 states, so if you bet from one of the following, you're eligible:

• Arizona
• Colorado
• Illinois
• Indiana
• Iowa
• Kansas
• Kentucky
• Louisiana
• Maryland
• New Jersey
• North Carolina
• Ohio
• Pennsylvania
• Tennessee
• Virginia

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